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RESEARCH AND DEVELOPMENT AT MILLENNIUM
Research and Development Engine
PUBLICATIONS 1996
Abitorabi M. A. Mackay C. R. Jerome E. H. Osorio O. Butcher E. C. Erle D. J. 1996 Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral and lung lymph. Journal 156:3111-3117
Adams J. Stein R. 1996 Novel inhibitors of the proteasome and their therapeutic use in inflammation. Annual Reports in Medicinal Chemistry. Section V, Chapter. 28:279-288
Albert D. L. Brodie S. J. Sasseville V. G. Ringler D. J. 1996 Peripheral blood eosinophils in owl monkeys is associated with increased eosinophilopoiesis yet depressed recruitment kinetics to the chemokine RANTES. Blood. 88:1718-1724
Asplund T. Brinck J. Suzuki M. Briskin M. J. Heldin P. 1998 Characterization of hyaluronan synthase from a human glioma cell line. Biochimica et Biophysica Acta. 1380:377-388
Baumann H. Morella K. K. White D. W. Dembski M. Bailon P. S. Kim H. Lai C. F. Tartaglia L. A. 1996 The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proceedings of the National Academy of Sciences of the United States of America. 93:8374-8378
Birdsall H. H. Green D. M. Trial J. Youker K. A. Burns A. Mackay C. LaRosa G. J. Hawkins H. K. Smith C. W. Michael L. Entmann M. L. Rossen R. D. 1996 Complement C5a, TGF-beta 1 and MCP-1, acting in sequence, stimulate infiltration of monocytes into ischemic myocardium and their accumulation in cardiac extracellular fluids within the first 1 to 5 hrs following reperfusion. Circulation. 95:685-692
Bochner B. S. Sterbinsky S. A. Briskin M. Saini S. S. MacGlashan D. W. Jr. 1996 Counter-receptors on human basophils for endothelial cell adhesion molecules. Journal of Immunology. 157:844-850
Borgia P. T. Iartchouk N. Riggle P. J. Winter K. R. Koltin Y. Bulawa C. E. 1996 The chsB gene of Aspergillus nidulans is necessary for normal hyphal growth and development. Fungal Genetics & Biology. 20:193-203. [Published erratum appears in Fungal Genet Biol, 1996, 20:314]
Briskin M. 1996 Organization, regulatory sequences and alternatively spliced transcripts of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) gene. Journal of Immunology. 155:2744-2486
Briskin M. J. Rott L. Butcher E. C. 1996 Structural requirements for mucosal vascular addressin binding to its lymphocyte receptor alpha 4 beta 7. Common themes among integrin-Ig interactions. Journal of Immunology. 156:719-726
Campbell J. J. Qin S. Bacon K. B. Mackay C. R. Butcher E. C. 1996 Biology of chemokine and classical chemoattractant receptors: Differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells. Journal of Cell Biology. 134:255-266
Chen H. Charlat O. Tartaglia L. A. Woolf E. A. Weng X. Ellis S. J. Lakey N. D. Culpepper J. Moore K. J. Breitbart R. E. Duyk G. M. Tepper R. I. Morgenstern J. P. 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:491-495
Chen Z. J. Parent L. Maniatis T. 1996 Site-specific phosphorylation of I-kappa-B-alpha by a novel ubiquitination-dependent protein kinase activity. Cell. 84:853-862
Choe H. Farzan M. Sun Y. Sullivan N. Rollins B. Ponath P. D. Wu L. Mackay C. R. LaRosa G. Newman W. Gerard N. Gerard C. Sodroski J. 1996 The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 85:1135-1148
Chua S. C. Jr. White D. W. Wu-Peng X. S. Liu S. M. Okada N. Kershaw E. E. Chung W. K. Power-Kehoe L. Chua M. Tartaglia L. A. Leibel R. L. 1996 Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes. 45:1141-1143
Chua S. C. Jr. Chung W. K. Wu-Peng X. S. Zhang Y. Liu S. M. Tartaglia L. Leibel R. L. 1996 Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 271:994-996
Conner E. M. Brand S. J. Davis J. M. Kang D. Y. Grisham M. B. 1996 Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease: Toxins, mediators, and modulators of gene expression. Inflammatory Bowel Diseases. 2:133-147
Devos R. Richards J. G. Campfield L. A. Tartaglia L. A. Guisez Y. van der Heyden J. Travernier J. Plaetinck G. Burn P. 1996 OB protein binds specifically to the choroid plexus of mice and rats. Proceedings of the National Academy of Sciences of the United States of America. 93:5668-5673
Dick L. R. Cruikshank A. A. Grenier L. Melandri F. D. Nunes S. L. Stein R. L. 1996 Mechanistic studies on the inactivation of the proteasome by lactacystin. A central role for clasto-lactacystin beta-lactone. Journal of Biological Chemistry. 271:7273-7276
Fukai K. Oh J. Karim M. A. Moore K. J. Kandil H. H. Ito H. Burger J. Spritz R.A. 1996 Homozygosity mapping of the gene for Chediak-Higashi syndrome to chromosome 1q42-q44 in a segment of conserved synteny that includes the mouse beige locus (bg). American Journal of Human Genetics. 59:620-624
Gonzalo J. A. Lloyd C. M. Kremer L. Finger E. Martinez-A. C. Siegelman M. H. Cybulsky M. Gutierrez-Ramos J. C. 1996 Eosinophil recruitment to the lung in a murine model of allergic inflammation: The role of T cells, chemokines, and adhesion receptors. Journal of Clinical Investigation. 98:2332-2345
Hesterberg P. E. Winsor-Hines D. Briskin M. J. Soler-Ferran D. Merrill C. Mackay C. R. Newman W. Ringler D. J. 1996 Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha-4 beta-7. Gastroenterology. 111:1373-1380
Hussoin M. S. Yeh C. G. 1996 The design of dual-acting compounds with PAF receptor antagonistic and 5-lipoxygenase inhibitory activities. Drugs of the Future. 21: 933-944
. 1996 Molecular & General Genetics. 251:153-160
Jones S. A. Wolf M. Qin S. Mackay C. R. Baggiolini M. 1996 Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2. Proceedings of the National Academy of Sciences of the United States of America. 93:6682-6686
Kumar A. G. Ballantyne C. M. Michael L. H. Kukielka G. L. Youker K. A. Lindsey M. L. Hawkins H. K. Birdsall H. H. Mackay C. R. LaRosa G. J. Rossen R. D. Smith C. W. Entman M. L. 1996 Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium. Circulation. 95:693-700
Li X. Abdi K. Rawn J. Mackay C. R. Mentzer S. J. 1996 LFA-1 and L-selectin regulation of recirculating lymphocyte tethering and rolling on lung microvascular endothelium. American Journal of Respiratory Cellular Molecular Biology. 14:398-406
Mackay C. R. 1996 Chemokine receptors and T cell chemotaxis. Journal of Experimental Medicine. 184:799-802
Mackay C. R. Andrew D. P. Briskin M. Ringler D. J. Butcher E. C. 1996 Phenotype and migration properties of three major subsets of tissue homing T cells in sheep. European Journal of Immunology. 26:2433-2439
Melandri F. Grenier L. Plamondon L. Huskey W. P. Stein R. L. 1996 Kinetic studies on the inhibition of isopeptidase T by ubiquitin aldehyde. Biochemistry. 35:12893-12900
Oin S. LaRosa G. Campbell J. J. Smith-Heath H. Kassam N. Shi X. Zheng L. Buthcher E. C. Mackay C. R. 1996 Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential. European Journal of Immunology. 26:640-647
Ponath P. D. Qin S. Post T. W. Wang J. Wu L. Gerard N. P. Newman W. Gerard C. Mackay C. R. 1996 Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. Journal of Experimental Medicine. 183:2437-2448
Ponath P. D. Qin S. Ringler D. J. Clark-Lewis I. Wang J. Kassam N. Smith H. Shi X. Gonzalo J. A. Newman W. Gutierrez-Ramos J. C. Mackay C. R. 1996 Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. Journal of Clinical Investigation . 97:604-612
Qin S. LaRosa G. Campbell J. J. Smith-Heath H. Kassam N. Shi X. Zeng L. Butcher E. C. Mackay C. R. 1996 Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: Correlation with transendothelial chemotactic potential. European Journal of Immunology. 26:640-647
Rand M. L. Warren J. S. Mansour M. K. Newman W. Ringler D. J. 1996 Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1. American Journal of Pathology. 148:855-864
Rankin J. A. Picarella D. E. Geba G. P. Temann U. A. Prasad B. DiCosmo B. Tarallo A. Stripp B. Whitsett J. Flavell R. A. 1996 Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proceedings of the National Academy of Sciences of the United States of America. 93:7821-7825
Rott L. S. Briskin M. J. Andrew D. P. Berg E. L. Butcher E. C. 1996 A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell ahdesion molecule-1. Comparison with vascular cell adhesion molecule-1 and correlation with b7 integrins and memory differentiation. Journal of Immunology. 156:3727-3736
Shroff H. N. Schwender C. F. Dottavio D. Yang L.-L. Briskin M. J. 1996 Small peptide inhibitors of a4b7 mediated MAdCAM-1 adhesion to lymphocytes. Bioorganic & Medicinal Chemistry Letters. 6:2495-2500
Shyjan A. M. Heldin P. Butcher E. C. Yoshino T. Briskin M. J. 1996 Functional cloning of the cDNA for a human hyaluronan synthase. Journal of Biological Chemistry. 271: 23395-23399
Stein R. L. Melandri F. Dick L. 1996 Kinetic characterization of the chymotryptic acivity of the 20S proteasome. Biochemistry. 35:3899-3908
Topper J. N. Cai J. Falb D. Gimbrone M. A. Jr. 1996 Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proceedings of the National Academy of Sciences of the United States of America. 93:10417-10422
Wu L. Ruffing N. Shi X. Newman W. Soler D. Mackay C. R. Qin S. 1996 Discrete steps in binding and signaling of interleukin-8 with its receptor. Journal of Biological Chemistry. 271:31202-31209
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