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PUBLICATIONS: PRINTER FRIENDLY LIST
The following is a partial list of publications by Millennium scientists in scientific journals selected to illustrate our expertise in major pathways relevant to our key therapeutic areas.
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PUBLICATIONS 2000
An W. F. Bowlby M. R. Bett M. Cao J. Ling H. P. Mendoza G. Hinson J. W. Mattsson K. I. Strassle B. W. Trimmer J. S. Rhodes K. J. 2000 Modulation of A-type potassium channels by a family of calcium sensors. Nature. 403:553-556
Auerbach W. Dunmore J. H. Fairchild-Huntress V. Fang Q. Auerbach A. B. Huszar D. Joyner A. L. 2000 Establishment and chimera analysis of 129/svEv- and C57BL/6-derived mouse embryonic stem cell lines. BioTechniques. 29:1024
Bertin J. Guo Y. Wang L. Srinivasula S. M. Jacobson M. D. Poyet J. L. Merriam S. Du M. Q. Dyer M. J. S. Robison K. E. DiStefano P. S. Alnermi E. S. 2000 CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. Journal of Biological Chemistry. 275:41082-41086
Blackburn C. Guan B. 2000 A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines: Access to new substitution patterns by solid-phase synthesis. Tetrahedron Letters. 41:1495-1500
Bray G. A. Tartaglia L. A. 2000 Medicinal strategies in the treatment of obesity. Nature. 404:672-677
Busfield S. J. Comrack C. A. Yu G. Chickering T. W. Smutko J. S. Zhou H. Leiby K. R. Holmgren L. M. Gearing D. P. Pan Y. 2000 Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. Genomics. 66:213-216
Coyle A. J. Lehar S. Lloyd C. Tian J. Delaney T. Manning S. Nguyen T. Burwell T. Schneider H. Gonzalo J.A. Gosselin M. Owen L.R. Rudd C.E. Guiterrez-Ramos J. C. 2000 The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity. 13:95-105
Coyle A. J. Lloyd C. M. Guiterrez-Ramos J. C. 2000 Biotherapeutic targets for the treatment of allergic airway disease. American Journal of Respiratory & Critical Care Medicine. 162:S170-S184
Deeds J. Cronin F. Duncan L. M. 2000 Patterns of melastatin mRNA expression in melanocytic tumors. Human Pathology. 31:1346-1356
Donoghue M. Hsieh F. Baronas E. Godbout K. Gosselin M. Stagliano N. Donovan M. Woolf B. Robison K. Jeyaseelan R. Breitbart R. E. Acton S. 2000 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circulation Research. 87:E1-E9
Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibanez CF, Rafii S, Hempstead BL. 2000 Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. 127(21):4531-40.
Fawcett P. Eichenberger P. Losick R. Youngman P. 2000 The transcriptional profile of early to middle sporulation in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 97:8063-8068
Frankel A. Man S. Elliott P. Adams J. Kerbel R. S. 2000 Lack of Multicellular Drug Resistance Observed in Human Ovarian and Prostate Carcinoma Treated with the Proteasome Inhibitor PS-341. Clinical Cancer Research. 6:3719-3728
Galvin K. M. Donovan M. J. Lynch C. A. Meyer R. I. Paul R. J. Lorenz J. N. Fairchild-Huntress V. Dixon K. L. Dunmore J. H. Gimbrone M. A. Falb D. Huszar D. 2000 A role for Smad6 in development and homeostasis of the cardiovascular system. Nature Genetics. 24:171-174
Gao W. Topham P. S. King J. A. Smiley S. T. Csizmadia V. Lu. B. Gerard C. J. Hancock W. W. 2000 Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection. Journal of Clinical Investigation. 105:35-44
Gonzalo J. A. Lloyd C. M. Peled A. Delaney T. Coyle A. J. Gutierrez-Ramos J. G. 2000 Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1 alpha in the inflammatory component of allergic airway disease. Journal of Immunology. 165:499-508
Gutierrez-Ramos J. C. Lloyd C. Kapsenberg M. L. Gonzalo J. A. Coyle A. J. 2000 Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung. Immunological Reviews. 177:31-42
Hancock W. W. Lu B. Gao W. Csizmadia B. Faia K. King J. A. Smiley S. T. Ling M. Gerard N. P. Gerard C. 2000 Requirement of the chemokine receptor CXCR3 for acute allograft rejection. Journal of Experimental Medicine. 192:1515-1519
Harriman G. C. B. Shao J. X. Luly J. R. 2000 Synthesis of 4-substituted 4-arylpiperdines. Tetrahedron Letters. 41:8853-8856
Huszar D. Varban M. L. Rinninger F. Feeley R. Arai T. Fairchild-Huntress V. Donovan M. J. Tall A. R. 2000 Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arteriosclerosis Thrombosis & Vascular Biology. 20:1068-1073
Jandrot-Perrus M. Busfield S. Lagrue A. H. Xiong X. M. Debili N. Chickering T. Le Couedic J.P. Goodearl A. Dussault B. Fraser C. Vainchenker W. Villeval J. L. 2000 Cloning, characterization, and functional studies of human and mouse glyhcoporotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 96:1798-1807
Lambrecht B.N. De Veerman M. Coyle A. J. Guiterrez-Ramos J.C. Thielemans K. Pauwels R. A. 2000 Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. Journal of Clinical Investigation. 106:551-559
Lightcap E. S. McCormack T. A. Pien C. S. Chau V. Adams J. Elliott P. J. 2000 Proteasome inhibition measurements: clinical application. Clinical Chemistry. 46:673-683
Lloyd C. M. Delaney T. Nguyen T. Tian J. Martinez C. Coyle A. J. Gutierrez-Ramos J. C. 2000 CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. Journal of Experimental Medicine. 191:265-273
McCarthy J. J. Hilfiker R. 2000 The use of single-nucleotide polymorphism maps in pharmacogenomics. Nature Biotechnology. 18:505-508
Read M. A. Brownell J. E. Gladysheva T. B. Hottelet M. Parent L. A. Coggins M. B. Pierce J. W. Podust V. N. Luo R. S. Chau V. Palombella V. J. 2000 Nedd8 modification of Cul-1 activates SCF beta(TrCp)-dependent ubiquitination of I kappa B alpha. Molecular & Cellular Biology. 20:2326-2333
Rottman J. B. Slavin A. J. Silva R. Weiner H. L. Gerard C. G. Hancock W. W. 2000 Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. European Journal of Immunology. 30:2372-2377
Sander C. 2000 Genomic medicine and the future of health care. Science. 287:1977-1978
Sica A. Saccani A. Bottazzi B. Bernasconi S. Allavena P. Gaetano B. Fei P. LaRosa G. Scotton C. Balkwill F. Mantovani A. 2000 Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma source. Journal of Immunology. 164:733-738
Smiley S.T. Csizmadia V. Gao W. Turka L.A. Hancock W.W. 2000 Differential effects of cyclosporin A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NF kappa B - Implications for tolerance induction. Transplantation. 70:415-419
Williams C. 2000 Biotechnology match making: Screening orphan ligands and receptors. Current Opinion in Biotechnology. 11:42-46
Williams C. Addona T. A. 2000 The integration of SPR biosensors with mass spectrometry: Possible applications for proteome analysis. Trends in Biotechnology. 18:45-48
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PUBLICATIONS 2001
Gonzalo JA, Tian J, Delaney T, Corcoran J, Rottman JB, Lora J, Al-garawi A, Kroczek R, Gutierrez-Ramos JC, Coyle AJ. 2001 ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nature Immunology. 2(7):597-604.
Gonzalo J. A. Delaney T. Corcoran J. Goodearl A. Guiterrez-Ramos J. C. Coyle A. J. 2001 Cutting edge: The related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation. Journal of Immunology. 166:1-5
Goodearl A. Viehover A. Vartanian T. 2001 Neuregulin-induced association of SOS Ras exchange protein with HER2 (erhB2)/HER3 (erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2 (erb62) interaction. Developmental Neuroscience. 23:25-30
Rottman JB, Smith T, Tonra JR, Ganley K, Bloom T, Silva R, Pierce B, Gutierrez-Ramos JC, Ozkaynak E, Coyle AJ. 2001 The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nature Immunology. 2(7):605-11.
Ozkaynak E, Gao W, Shemmeri N, Wang C, Gutierrez-Ramos JC, Amaral J, Qin S, Rottman JB, Coyle AJ, Hancock WW. 2001 Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nature Immunology. 2(7):591-6.
Pantoliano MW, Petrella EC, Kwasnoski JD, Lobanov VS, Myslik J, Graf E, Carver T, Asel E, Springer BA, Lane P, Salemme FR. 2001 High-density miniaturized thermal shift assays as a general strategy for drug discovery. Journal of Biomolecular Screening. 6(6):429-40.
Stagliano NE, Carpino AJ, Ross JS, Donovan M. 2001 Vascular gene discovery using laser capture microdissection of human blood vessels and quantitative PCR. Annals of the New York Academy of Sciences. 947:344-9.
Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS. 2001 Atherosclerosis: a cancer of the blood vessels? American Journal of Clinical Pathology. 116 Suppl:S97-107.
Coyle AJ, Gutierrez-Ramos JC. 2001 The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nature Immunology. 2(3):203-9.
Herman MP, Sukhova GK, Libby P, Gerdes N, Tang N, Horton DB, Kilbride M, Breitbart RE, Chun M, Schonbeck U. 2001 Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling. Circulation. 104(16):1899-904.
Wiley R. E. Palmer K. Gajewska B. U. Stampfil M. R. Alvarez D. Coyle A. J. Guiterrez-Ramos J. C. Jordana M. Expression of the Th1 chemokine IFN-gamma-inducible protein 10 in the airway alters mucosal allergic sensitization in mice. 2001 Journal of Immunology. 166:2750-2759
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PUBLICATIONS 2002
Grant EP, Picarella D, Burwell T, Delaney T, Croci A, Avitahl N, Humbles AA, Gutierrez-Ramos JC, Briskin M, Gerard C, Coyle AJ. 2002 Essential Role for the C5a Receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis Journal of Experimental Medicine 196(11):1461-71.
Alden C, Smith P, Morton D. 2002 Application of genetically altered models as replacement for the lifetime mouse bioassay in pharmaceutical development. Toxicology and Pathology. 30(1):135-8.
Yang RB, Ng CK, Wasserman SM, Colman SD, Shenoy S, Mehraban F, Komuves LG, Tomlinson JE, Topper JN. 2002 Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. Journal of Biological Chemistry. 277(48):46364-73.
Orlowski RZ, Stinchcombe TE, Mitchell BS, Shea TC, Baldwin AS, Stahl S, Adams J, Esseltine DL, Elliott PJ, Pien CS, Guerciolini R, Anderson JK, Depcik-Smith ND, Bhagat R, Lehman MJ, Novick SC, O'Connor OA, Soignet SL. 2002. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. Journal of Clinical Oncology. 20(22):4420-7.
Teng PI, Dichiara MR, Komuves LG, Abe K, Quertermous T, Topper JN. 2002 Inducible and selective transgene expression in murine vascular endothelium. Physiological Genomics. 11(2):99-107.
Dales NA, Gould AE, Brown JA, Calderwood EF, Guan B, Minor CA, Gavin JM, Hales P, Kaushik VK, Stewart M, Tummino PJ, Vickers CS, Ocain TD, Patane MA. 2002 Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. Journal of the American Chemical Society.124(40):11852-3.
Wasserman SM, Mehraban F, Komuves LG, Yang RB, Tomlinson JE, Zhang Y, Spriggs F, Topper JN. 2002 Gene expression profile of human endothelial cells exposed to sustained fluid shear stress. Physiological Genomics. 12(1):13-23.
Mistry SK, Burwell TJ, Chambers RM, Rudolph-Owen L, Spaltmann F, Cook WJ, Morris SM Jr. 2002 Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus. American Journal of Physiology — Gastrointestinal and Liver Physiology. 282(2):G375-81.
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PUBLICATIONS 2003
Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. 2003 Chronic Inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 112(12):1821-30.
Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. 2003 Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108(23):2926-33
Tomlinson JE, Topper JN. 2003 New insights into endothelial diversity. Current Atherosclerosis Reports. 5(3):223-9.
Yang RB, Ng CK, Wasserman SM, Komuves LG, Gerritsen ME, Topper JN. 2003 A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling. Journal of Biological Chemistry. 278(35):33232-8.
Lippert E, Yowe DL, Gonzalo JA, Justice JP, Webster JM, Fedyk ER, Hodge M, Miller C, Gutierrez-Ramos JC, Borrego F, Keane-Myers A, Druey KM. 2003. Role of regulator of G protein signaling 16 in inflammation-induced T lymphocyte migration and activation. The Journal of Immunology. 171(3):1542-55.
Richardson P.G. Barlogie B. Berenson J. Singhal S. Jagannath S. Irwin D. Rajkumar S.V. Srkalovic G. Alsina M. Alexanian R. Siegel D. Orlowski R.Z. Kuter D. Limentani S.A. Lee S. Hideshima T. Esseltine D.L. Kauffman M. Adams J. Schenkein D.P. Anderson K.C. 2003 A phase 2 study of bortezomib in relapsed, refractory myeloma. New England Journal of Medicine. 348(26):2609-17.
Varilo T, Paunio T, Parker A, Perola M, Meyer J, Terwilliger JD, Peltonen L. 2003
The interval of linkage disequilibrium (LD) detected with microsatellite and SNP markers in chromosomes of Finnish populations with different histories. Human Molecular Genetics. 12(1):51-9.
Ross JS, Ginsburg GS. 2003 The Integration of Molecular Diagnostics with Therapeutics. American Journal of Clinical Pathology 119(1):26-36.
Ross JS, Gray K, Gray GS, Worland PJ, Rolfe M. 2003 Anticancer antibodies. American Journal of Clinical Pathology. 119(4):472-85.
Roubenoff R. 2003 Catabolism of Aging: is it an inflammatory process?
Current Opinions in Clinical Nutrition and Metabolic Care 6(3):295-9.
Castro AC, Dang LC, Soucy F, Grenier L, Mazdiyasni H, Hottelet M, Parent L, Pien C, Palombella V, Adams J. 2003 Novel IKK Inhibitors: B-Carbolines.
Bioorganic and Medicinal Chemistry Letters 13(14):2419-22.
Grant EP, Coyle AJ, Gutierrez-Ramos JC 2003 Informatics and the immune system: the expanding IL-1 and B7 protein families. Seminars in Immunology. 15(4):225-31.
Sanchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutierrez-Ramos JC, Coyle AJ, Strom TB. 2003 Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nature Immunology 4(11):1093-101.
McCarthy JJ, Meyer J, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ; GenQuest multicenter study. 2003 Evidence for substantial effect modification by gender in a large-scale genetic association study of metabolic syndrome among coronary heart disease patients. Human Genetics 114(1):87-98.
McCarthy JJ, Lewitzky S, Reeves C, Permutt A, Glaser B, Groop LC, Lehner T, Meyer JM. 2003 Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations. Human Heredity. 55(4):163-70.
McCarthy JJ, Lehner T, Reeves C, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ; Genequest investigators. 2003 Association of genetic variants in the HDL receptor, SR-B1, with abnormal lipids in women with coronary artery disease. Journal of Molecular Genetics. 40(6):453-8.
Ross JS, Linette GP, Stec J, Ross MS, Anwar S, Boguniewicz A. 2003 DNA ploidy and cell cycle analysis in breast cancer. American Journal of Clinical Pathology. 120 Suppl:S72-84.
Carlson JA, Slominski A, Linette GP, Mysliborski J, Hill J, Mihm MC Jr, Ross JS. 2003 Malignant melanoma 2003: predisposition, diagnosis, prognosis, and staging. American Journal of Clinical Pathology.120 Suppl:S101-27.
Ross JS, Fletcher JA, Bloom KJ, Linette GP, Stec J, Clark E, Ayers M, Symmans WF, Pusztai L, Hortobagyi GN. 2003 HER-2/neu testing in breast cancer. American Journal of Clinical Pathology.120 Suppl:S53-71.
Bembenek ME, Jain S, Prack A, Li P, Chee L, Cao W, Spurling H, Roy R, Fish S, Rokas M, Parsons T, Meyers R. 2003 Development of a high-throughput assay for two inositol-specific phospholipase Cs using a scintillation proximity format. Assay and Drug Development Technologies. 1(3):435-43.
Ficenec D, Osborne M, Pradines J, Richards D, Felciano R, Cho RJ, Chen RO, Liefeld T, Owen J, Ruttenberg A, Reich C, Horvath J, Clark T. 2003 Computational knowledge integration in biopharmaceutical research. Briefings in Bioinformatics. 4(3):260-78.
Darwin KH, Ehrt S, Gutierrez-Ramos JC, Weich N, Nathan CF. 2003 The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science. 302(5652):1963-6.
Schmidt-Supprian M, Courtois G, Tian J, Coyle AJ, Israel A, Rajewsky K, Pasparakis M. 2003 Mature T cells depend on signaling through the IKK complex. Immunity. 19(3):377-89.
Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. 2003 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nature Immunology 4(5):491-6.
Sabatos CA, Chakravarti S, Cha E, Schubart A, Sanchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK. 2003 Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nature Immunology. 4(11):1102-10.
Bakewell SJ, Nestor P, Prasad S, Tomasson MH, Dowland N, Mehrotra M, Scarborough R, Kanter J, Abe K, Phillips D, Weilbaecher KN. 2003 Platelet and osteoclast beta3 integrins are critical for bone metastasis. Proceedings of the National Academy of Sciences. 100(24):14205-10.
Donoghue M, Wakimoto H, Maguire CT, Acton S, Hales P, Stagliano N, Fairchild-Huntress V, Xu J, Lorenz JN, Kadambi V, Berul CI, Breitbart RE. 2003 Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. Journal of Molecular and Cellular Cardiology. 35(9):1043-53.
Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jehanno M, Viala J, Tedin K, Taha MK, Labigne A, Zahringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ. 2003 Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science. 300(5625):1584-7.
Williams JA. 2003 Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma. Drug News and Perspectives. 16(10):657-62.
Gretler DD. 2003 Pharmacokinetic and pharmacodynamic properties of eptifabatide in healthy subjects receiving unfractionated heparin or the low-molecular-weight heparin enoxaparin. Clinical Therapeutics.25(10):2564-74.
Andre P, LaRocca T, Delaney SM, Lin PH, Vincent D, Sinha U, Conley PB, Phillips DR. 2003 Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis. Circulation. 108(21):2697-703.
Prasad KS, Andre P, He M, Bao M, Manganello J, Phillips DR. 2003 Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling. Proceedings of the National Academy of Sciences. 100(21):12367-71.
Gerritsen ME, Tomlinson JE, Zlot C, Ziman M, Hwang S. 2003 Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells. British Journal of Pharmacology. 140(4):595-610.
Prasad KS, Andre P, Yan Y, Phillips DR. 2003 The platelet CD40L/GP IIb-IIIa axis in atherothrombotic disease. Current Opinions in Hematology. 10(5):356-61.
Conley PB, Delaney SM. 2003 Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis. Current Opinions in Hematology. 10(5):333-8.
Andre P, Delaney SM, LaRocca T, Vincent D, DeGuzman F, Jurek M, Koller B, Phillips DR, Conley PB. 2003 P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. Journal of Clinical Investigation. 112(3):398-406.
Xu H, Dembski M, Yang Q, Yang D, Moriarty A, Tayber O, Chen H, Kapeller R, Tartaglia LA. 2003 Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. Journal of Biological Chemistry. 278(32):30187-92.
Adams J. 2003 The proteasome: structure, function, and role in the cell. Cancer Treatment Reviews. 29 Suppl 1:3-9.
Chen Y, Miller C, Mosher R, Zhao X, Deeds J, Morrissey M, Bryant B, Yang D, Meyer R, Cronin F, Gostout BS, Smith-McCune K, Schlegel R. 2003 Identification of cervical cancer markers by cDNA and tissue microarrays. Cancer Research. 63(8):1927-35.
Wu L, Pan J, Thoroddsen V, Wysong DR, Blackman RK, Bulawa CE, Gould AE, Ocain TD, Dick LR, Errada P, Dorr PK, Parkinson T, Wood T, Kornitzer D, Weissman Z, Willis IM, McGovern K. 2003 Novel small-molecule inhibitors of RNA polymerase III. Eukaryotic Cell. 2(2):256-64.
Adams J. 2003 Potential for proteasome inhibition in the treatment of cancer. Drug Discovery Today. 8(7):307-15.
Nannizzi-Alaimo L, Alves VL, Phillips DR. 2003 Inhibitory effects of glycoprotein IIb/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation. Circulation. 107(8):1123-8.
Ross J, Gray K, Schenkein D, Greene B, Gray GS, Shulok J, Worland PJ, Celniker A, Rolfe M. 2003 Antibody-based therapeutics in oncology. Expert Review of Anticancer Therapy. 3(1):107-21.
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PUBLICATIONS 2004
Sasseville VG, Lane JH, Kadambi VJ, Bouchard P, Lee FW, Balani SK, Miwa GT, Smith PF, Alden CL. 2004 Testing paradigm for prediction of development-limiting barriers and human drug toxicity. Chem Biol Interactions 150(1):9-25.
Veiby OP, Read MA. 2004 Chemoresistance: impact of nuclear factor (NF)-kappaB inhibition by small interfering RNA. Commentary re J. Guo et al., Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the NF-kappaB p65 subunit. Clin Cancer Res 2004;10:3333-3341. Clinical Cancer Research. 10(10):3262-4.
Kuhn E, Wu J, Karl J, Liao H, Zolg W, Guild B. 2004 Quantification of C-reactive protein in the serum of patients with rheumatoid arthritis using multiple reaction monitoring mass spectrometry and 13C-labeled peptide standards. Proteomics. 4(4):1175-86.
Henry MD, Wen S, Silva MD, Chandra S, Milton M, Worland PJ. 2004 A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer. Cancer Research. 64(21):7995-8001.
Pradines J, Rudolph-Owen L, Hunter J, Leroy P, Cary M, Coopersmith R, Dancik V, Eltsefon Y, Farutin V, Leroy C, Rees J, Rose D, Rowley S, Ruttenberg A, Wieghardt P, Sander C, Reich C. 2004 Detection of activity centers in cellular pathways using transcript profiling. Journal of Pharmaceutical Statistics. 14(3):701-21.
Sappal DS, McClendon AK, Fleming JA, Thoroddsen V, Connolly K, Reimer C, Blackman RK, Bulawa CE, Osheroff N, Charlton P, Rudolph-Owen LA. 2004 Biological characterization of MLN944: a potent DNA binding agent. Molecular Cancer Therapeutics. 3(1):47-58.
Fang L, Yan Y, Komuves LG, Yonkovich S, Sullivan CM, Stringer B, Galbraith S, Lokker NA, Hwang SS, Nurden P, Phillips DR, Giese NA. 2004 PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle. Arteriosclerosis, Thrombosis and Vascular Biology. 24(4):787-92.
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW. 2004 ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. Journal of Biological Chemistry. 279(17):17996-8007.
Ross JS, Schenkein DP, Pietrusko R, Rolfe M, Linette GP, Stec J, Stagliano NE, Ginsburg GS, Symmans WF, Pusztai L, Hortobagyi GN. 2004 Targeted therapies for cancer 2004. American Journal of Clinical Pathology.122 (4):598-609.
Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. 2004 Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proceedings of the National Academy of Sciences. 101(13):4566-71.
Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S, Coyle AJ, Rajewsky K. 2004 I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion. Journal of Immunology 173(3):1612-9.
Coyle AJ, Gutierrez-Ramos JC. 2004 The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Seminars in Immunopathology. 25(3-4):349-59.
Heath JA, Mehrotra MM, Chi S, Yu JC, Hutchaleelaha A, Hollenbach SJ, Giese NA, Scarborough RM, Pandey A. 2004 Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor. Bioorganic Medicinal Chemistry Letters. 14(19):4867-72.
Clark JJ, Cools J, Curley DP, Yu JC, Lokker NA, Giese NA, Gilliland DG. 2004 Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. Blood. 104(9):2867-72.
Blackman RK, Amidon BS. 2004 Microarray approach for cloned library quality assessment and the comprehensive identification of positives from library screens. Biotechniques. 37(4):536, 538, 540.
Scarborough RM. 2003 Protease-activated receptor-2 antagonists and agonists. Curr Med Chem Cardiovasc Hematol Agents. (1):73-82.
Bembenek ME, Roy R, Li P, Chee L, Jain S, Parsons T. A homogeneous scintillation proximity format for monitoring the activity of recombinant human long-chain-fatty-acyl-CoA synthetase 5. Assay and Drug Development Technologies. 2(3):300-7.
Roubenoff R. 2004 Sarcopenic obesity: the confluence of two epidemics. Obesity Research. 12(6):887-8.
Yang P, Macdonald F. 2004 Solution stability of factor Xa inhibitors as a function of pH. Drug Development and Industrial Pharmacy. 30(9):967-73.
Ross JS, Schenkein DP, Kashala O, Linette GP, Stec J, Symmans WF, Pusztai L, Hortobagyi GN. 2004 Pharmacogenomics. Advances in Anatomic Pathology. 11(4):211-20.
Balani SK, Li P, Nguyen J, Cardoza K, Zeng H, Mu DX, Wu JT, Gan LS, Lee FW. 2004 Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in Guinea pigs and mice using serial sampling. Drug Metabolism and Distribution. 32(10):1092-5.
Trepicchio WL, Williams GA, Essayan D, Hall ST, Harty LC, Shaw PM, Spear BB, Wang SJ, Watson ML. 2004 Pharmacogenomic data submissions to the FDA: clinical case studies. Pharmacogenomics. 5(5):519-24.
Marsilje TH, Roses JB, Calderwood EF, Stroud SG, Forsyth NE, Blackburn C, Yowe DL, Miao W, Drabic SV, Bohane MD, Scott Daniels J, Li P, Wu L, Patane MA, Claiborne CF. 2004 Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R). Bioorganic and Medicinal Chemistry Letters. 14(14):3721-5.
Adams J, Kauffman M. 2004 Development of the proteasome inhibitor Velcade (Bortezomib). Cancer Investigation. 22(2):304-11.
Sullivan B, Addona TA, Carr SA. 2004 Selective detection of glycopeptides on ion trap mass spectrometers. Annals of Chemistry. 76(11):3112-8.
Ayers M, Symmans WF, Stec J, Damokosh AI, Clark E, Hess K, Lecocke M, Metivier J, Booser D, Ibrahim N, Valero V, Royce M, Arun B, Whitman G, Ross J, Sneige N, Hortobagyi GN, Pusztai L. 2004 Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer. Journal of Clinical Oncology. 22(12):2284-93.
Perreault M, Istrate N, Wang L, Nichols AJ, Tozzo E, Stricker-Krongrad A. 2004 Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss. International Journal of Obesity. 28(7):879-85.
Gretler DD, Guerciolini R, Williams PJ. 2004 Pharmacokinetic and pharmacodynamic properties of eptifibatide in subjects with normal or impaired renal function. Clinical Therapeutics. 26(3):390-8.
Jia ZJ, Su T, Zuckett JF, Wu Y, Goldman EA, Li W, Zhang P, Clizbe LA, Song Y, Bauer SM, Huang W, Woolfrey J, Sinha U, Arfsten AE, Hutchaleelaha A, Hollenbach SJ, Lambing JL, Scarborough RM, Zhu BY. 2004 N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors. Bioorganic and Medicinal Chemistry Letters. 14(9):2073-8.
Mehrotra MM, Heath JA, Smyth MS, Pandey A, Rose JW, Seroogy JM, Volkots DL, Nannizzi-Alaimo L, Park GL, Lambing JL, Hollenbach SJ, Scarborough RM. 2004 Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists. Journal of Medicinal Chemistry. 47(8):2037-61.
Cherry M, Williams DH. 2004 Recent kinase and kinase inhibitor X-ray structures: mechanisms of inhibition and selectivity insights. Current Opinions in Medicinal Chemistry. 11(6):663-73.
Vos TJ, Caracoti A, Che JL, Dai M, Farrer CA, Forsyth NE, Drabic SV, Horlick RA, Lamppu D, Yowe DL, Balani S, Li P, Zeng H, Joseph IB, Rodriguez LE, Maguire MP, Patane MA, Claiborne CF. 2004 Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. Journal of Medicinal Chemistry. 47(7):1602-4.
Zhang P, Bao L, Zuckett JF, Jia ZJ, Woolfrey J, Arfsten A, Edwards S, Sinha U, Hutchaleelaha A, Lambing JL, Hollenbach SJ, Scarborough RM, Zhu BY. 2004 Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity. Bioorganic and Medicinal Chemistry Letters. 14(4):989-93.
Gu W, Geddes BJ, Zhang C, Foley KP, Stricker-Krongrad A. 2004 The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice. Journal of Molecular Neuroscience. 22(1-2):93-103.
Liao H, Wu J, Kuhn E, Chin W, Chang B, Jones MD, O'neil S, Clauser KR, Karl J, Hasler F, Roubenoff R, Zolg W, Guild BC. 2004 Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis. Arthritis and Rheumatism 50(12):3792-803.
Teupser D, Pavlides S, Tan M, Gutierrez-Ramos JC, Kolbeck R, Breslow JL. 2004 Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proceedings of the National Academy of Sciences. Dec 13; [Epub ahead of print]
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